Enzymatic Glycosylation of Triazole-Linked GlcNAc/Glc-Peptides: Synthesis, Stability and Anti-HIV Activity of Triazole-Linked HIV-1 gp41 Glycopeptide C34 Analogues

Recognition of HIV TAR RNA by triazole linked neomycin dimers.

A series of neomycin dimers have been synthesized using 'click chemistry' with varying linker functionality and length to target the TAR RNA region of HIV virus. TAR (trans activation response) RNA region, a 59 base pair stem loop structure located at 5'-end of all nascent HIV-1 transcripts interacts with a key regulatory protein, Tat, and necessitates the replication of HIV-1 virus. Neomycin, ...

Synthesis and biological properties of triazole-linked locked nucleic acid.

We have synthesized and studied the biological and biophysical properties of triazole-linked ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole linkage gave high binding affinity when incorporated at the 3' or 5' termini of oligonucleotides, but low binding affinity at internal positions. Antisense oligonucleotides (ASOs) and siRNAs containing triazole dimer...

Synthesis of triazole-linked morpholino oligonucleotides via Cu catalysed cycloaddition†

Synthesis of 1,2,3- Triazole Nucleoside Analogues

Both 1,2,3-triazoles and nucleosides have proved to be useful pharmacophores for antiviral and anticancer agents. A series of novel 1,2,3-triazole nucleoside analogues were designed and synthesized in order to find new antiviral or antitumor compounds. KEYWORD: Triazole; Nucleoside; Virus; Cancer International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The au...

Synthesis and anticancer activity of glucosylated podophyllotoxin derivatives linked via 4β-triazole rings.

A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Most of these triazole derivatives have good anticancer activity. Among them, compound...